HLA-2

HLA

HLA2

	CODE	PROBE	ACC.N	MAP	UCSC May 2004	REMARKS
	10K	RP11-300B2	AL355531	10q26.3	chr10:131,108,576-131,322,463
		RP11-296H2	AL135793	10q26.13	chr10:123,907,460-124,121,322
	10J	RP11-829M16	AQ800180	10q23.31	chr10:92,526,680-92,680,990
B-H
	10I	RP11-1036I20	BES	10q23.2	chr10:89,041,485-89,237,407	HLA2p&2p
B-H	NLE	CH271-216H2	BES		chr10:89,294,947/chr10:52,022,220	HLA2p
B-H	NLE	CH271-286O11	BES		chr10:89,293,716/chr10:52,022,295	HLA2p
	10E	RP11-90N8	BES	10q11.23	chr10:51,442,402-51,622,394	HLA2p&2p
	10F	RP11-201B18	BES	10q21.1	chr10:58,153,525-58,301,654
	10G	RP11-23J10			chr10:58,375,675-58,537,685
	10H	RP11-537A6	AL512656	10q22.2	chr10:74,657,736-74,820,636
		RP11-717O2	BES	10q23.1	chr10:84,795,601-84,982,857
	10I	RP11-1036I20	BES	10q23.2	chr10:89,041,485-89,237,407	HLA2p&2p
B-H		I &E Split on HLA2p due to a paracentric inversion in HSA
	10E	RP11-90N8	BES	10q11.23	chr10:51,442,402-51,622,394	HLA2p&2p
		RP11-285G1	AL353801	10q11.21	chr10:44,640,088-44,862,577
	10D	RP11-351D16	AC010864	10q11.21	chr10:42,781,197-42,986,992
		CENTROMERE
	10C	RP11-774G16	BES	10p12.1	chr10:28,304,146-28,502,830
		RP11-958P22	BES	10p12.1	chr10:24,120,160-24,307,409
	10B	RP11-344N19	BES	10p12.2	chr10:23,942,660-24,115,999	HLA2q&3q
B-A	NLE	CH271-429J4	BES		chr10:24,162,148/chr4:110,646,805	HyA translocation HLA2q
	4H	RP11-1091M15	BES	4q25	chr4:110,517,162-110,721,162	HLA2q&3q
	4I	RP11-232M14	AQ486148	4q26	chr4:117,254,015-117,433,051
		RP11-928N3	BES	4q26	chr4:118,322,280-118,538,740
		RP11-45L5	BES	4q28.3	chr4:135,416,552-135,561,686
	4J	RP11-124P22	BES	4q31.1	chr4:140,672,267-140,864,927
B-N	NLE	CH271-340F4	BES		chr22:31,155,960/chr4:140.754.577	HLA2&8
		RP11-780M14	AC104090	4q31.21	chr4:145,013,767-145,114,804
	4K	RP11-335L23	AC019193	4q35.1	chr4:184,275,396-184,453,118

Legend. HLA ideogram (left) showing the synteny block correspondence with the human chromosome(s) (right). Internal red numbers indicate the human corresponding chromosome. Blue and red arrows indicate concordant (blue) and inverse (red) sequence polarity (orientation) with respect to humans. Black numbers (chromosome) followed by a letter (BAC), on the right, indicate specific BACs as reported in the Supplemental Table S1.

B-H Breaks in lineages leading to HSA	B-L Breaks in lineages leading to Lar	HyA: Hylobatidae ancestor
B-A Breaks in hylobatidae ancestor	B-N Breaks in lineages leading to Nomascus	Splitting clones

homerocchi@biologia.uniba.it