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Immunoglobulin genes IGH (14q32.33) in normal cells Atlas IGH |
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| Primers (5' -> 3') | Clone |
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dJ998D24 | From 337bp upstream of the IGHA1
transmembrane exon to 5471bp upstream of the most proximal D
gene (D7-27) located at 14q32.3. Information from Tim Poulsen TISP@herlevhosp.kbhamt.dk; see the location (Figure) |
| dJ1098L17 |
(a very faint signal at 15q11.2 *) It contains Variable regions; do not contain JH or Constant regions (Antonino Neri, personal communication; filobus@mailserver.unimi.it). |
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dJ1179A6 | chimeric: 14q32.33 +15q11.2 * |
| dJ826O13 | chimeric: 14q32.33 +15q11.2 * | |
| dJ829D3 | chimeric: 14q32.33 +15q11.2 *+8 | |
| dJ872M24 | chimeric: 14q32.33 +15q11.2 * | |
| * The signal at 15q12 is due to IGHV and IGHD orphons present at this site [Pallares N. et al., Exp. Clin. Immunogenet. 16, 36-60 (1999); Ruiz M. et al., Exp. Clin. Immunogenet. 16, 173-184 (1999)] | ||
For details see the paper Poulsen TS, Silahtaroglu AN, Gisselo CG, Gaarsdal E, Rasmussen T, Tommerup N, Johnsen HE: Detection of illegitimate rearrangement within the immunoglobulin locus on 14q32.3 in B-cell malignancies using end-sequenced probes. Genes Chromosomes Cancer. 2001 Nov;32(3):265-74..
See also:
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