SUPPLEMENTAL FILE SF2

(Refer to Supplemental table ST2, ST4)

Chromosomal flow changes from Hylobatidae ancestor to HLA
(click to enlarge each Figure)

The symbol Green hatched boxes include chromosomes involved in the rearrangement; blue dotted boxes contain intermediate chromosomes, while red boxes indicate the final chromosomal form. Red numbers internal to chromosomes indicate the human chromosome corresponding to that region. Numbers followed by a letter on the right of chromosomes indicate a specific human BAC as reported in both ST1 and ST5 Supplemental Tables. The numbers on the right of the final Hylobatidae ancestor chromosome (HyA) represent arbitrarily chosen points useful in indicating its composition, as reported in Supplemental Table ST4. Usually they correspond to a BAC. When found at the borders of the synteny blocks they identify two BACs facing each other following a rearrangement.:: (double dots) indicate breakage and reunion. NEC stands for new evolutionary centromere.  Inactivated centromere.

References:
- Cardone, M.F., Lomiento, M., Teti, M.G., Misceo, D., Roberto, R., Capozzi, O., D'Addabbo, P., Ventura, M., Rocchi, M., and Archidiacono, N. 2007.
Evolutionary history of chromosome 11 featuring four distinct centromere repositioning events in Catarrhini. Genomics 90: 35-43.
- Jauch, A., Daumer, C., Lichter, P., Murken, J., Schroeder-Kurth, T., and Cremer, T. 1990.
Chromosomal in situ suppression hybridization of human gonosomes and autosomes and its use in clinical cytogenetics. Hum. Genet. 85: 145-150.
- Roberto, R., Capozzi, O., Wilson, R.K., Mardis, E.R., Lomiento, M., Tuzun, E., Cheng, Z., Mootnick, A.R., Archidiacono, N., Rocchi, M. et al. 2007.
Molecular refinement of gibbon genome rearrangement. Genome Res. 17: 249-257.