HLA8, HLA10, HLA13, HLA16:
These four chromosomes stem from a series of complex rearrangements generating
(i) an intermediate, generated by a Robertsonian fusion involving HyA24 and HyA27, shared by NLE/SSY/HLA, but not, very likely, by Hoolock (note that HyA24/HyA27 association is present also in NLE);
(ii) a second intermediate generated by a HyA3/HyA16 translocation also resulted in the generation of HLA10.
The two intermediates were then involved, along with HyA11, in generating HLA8, 13, and 16. The latter rearrangement was the most complex we have detected. An internal loop lead to the excision of the central part of intermediate 2 to form HLA.