Queste pagine illustrano l'organizzazione dei cromosomi (sintenia) dell'orango, studiata presso il Dipartimento di Biologia della Università di Bari, come parte integrante del lavoro uscito su Nature 469:529-533 (2011).

Orangutan synteny organization, studied by FISH1
Pongo pygmaeus abelii, Sumatra

This Web site is part of the paper "Comparative and demographic analysis of orang-utan genomes", by D.P. Locke et al. (Nature, 469:529-533, 2011)

Karyotype (Sumatra and Borneo2); satellite DNA;

Chromosome by chromosome*:
*The used chromosome nomenclature is the phylogenetic one, but in Arabic figures instead of Latin figures (to simplify orang-human comparison).

PPY3
1
3
4
5
6
7
8
9
PPY4
I
V
X
PPY5
1
2
3
4
5
6
7
8
9
HSA
1
2p
2q
3
4
5
6
7
8
9
10
11
12
13
14
15
16
1177
18
19
20
21
22

co-linear chromosomes6
rearranged chromosomes

(1) Green flourescently highlighted columns refer to orang clones (PPAE- clones: BAC clones from the CHORI-276 BAC library) that span the human/orang breakpoints; all other rows refer to human BACs
(2) Sumatra and Borneo karyotypes differ for a pericentric inversion of chromosome 3 occurred in Sumatra (derivative with respect to Borneo).
(3-4-5) Chromosome nomenclature:  3McConkey: Cytogenet. Genome Res. 105: 157-158 (2004);  4Phylogenetic nomenclature;  5classical nomenclature.
(6) not considering small inversions (<4-5Mb).

Abbreviations used in the pictures showing the evolutionary history of chromosomes
Hominoids
PTR Pan troglodytes common chimp
PPA Pan paniscus pigmy chimp
GGO Gorilla gorilla gorilla
PPY Pongo pygmaeus abelii orangutan (Sumatra)
PPY Pongo pygmaeus pygmaeus orangutan (Borneo)
OWM
PPY Macaca mulatta rhesus monkey
PHA Papio hamadryas sacred baboon
CAE Cercopithecus aethiops African green monkey
NFA Macaca fascicularis crab-eating macaque
PCR
TCR		 Presbytis cristata =
= Tachypithecus cristatus		 silvered-leaf monkey

   
NWM
CJA Callithrix jacchus common marmoset
CMO Callicebus moloch dusky titi
SSC Saimiri sciureus squirrel monkey

   
Non-primate mammals
BTO Bos taurus cattle
ECA Equus caballus horse
SUS Sus scrofa pig
FCA Felix catus cat