HyA1 and HyA25:
Our interpretation of the origin of these two chromosomes is at variance with the literature (Muller et al. 2003). This discrepancy is essentially a small segment of chromosome 7 on HyA25 that was not previously detected and which was conserved in both HLA and NLE. Nie et al.(2001) used NLE as a probe on HHO and found the hybridization signal associated with HSA2 on HHO4. These Authors however did not report a 2/7 association for this chromosome even if we now know that a small segment of HSA 7 is present in NLE 20. BAC-FISH results directly indicate that this segment is present in NLE and indirectly show that it is present in HHO, therefore the Hylobatidae ancestral karyotype must be accordingly modified.
HyA2, HyA15, and HyA21:
No discrepancy with literature data.
Muller, S., Hollatz, M., and Wienberg, J. 2003. Chromosomal phylogeny and evolution of gibbons (Hylobatidae). Hum. Genet. 113: 493-501.
Nie, W., Rens, W., Wang, J., and Yang, F. 2001. Conserved chromosome segments in Hylobates hoolock revealed by human and H. leucogenys paint probes. Cytogenet. Cell Genet. 92: 248-253.
Roberto, R., Capozzi, O., Wilson, R.K., Mardis, E.R., Lomiento, M., Tuzun, E., Cheng, Z., Mootnick, A.R., Archidiacono, N., Rocchi, M. et al. 2007. Molecular refinement of gibbon genome rearrangement. Genome Res. 17: 249-257.