Queste pagine illustrano l'organizzazione dei cromosomi (sintenia) del gibbone dalle guance bianche (Nomascus leucogenys), studiata presso il Dipartimento di Biologia della Università di Bari, come parte integrante del lavoro di Nature, 11 settembre 2014.
Nomascus leucogenys, NLE (white cheeked crested gibbon)
NLE karyotype (DAPI) NLE karyogram Hominoidea ancestral karyotype
NLE synteny blocks arrangement (summary) HSA synteny blocks arrangement (summary)
| 21 | 22a/b | 23 | 24 | 25 | X | ||||||||||||||||||||
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Human chromosomes contributing to each NLE chromosome
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| NLE |
1b
|
2
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3
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4
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5
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6
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7
|
8
|
9
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10
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11
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12
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13
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14
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15
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16
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17
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18
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19
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20
|
21 | 22b | 23 | 24 | 25 |
| HSA | 6 9 14 |
5 16 |
6 10 |
3 8 11 18 |
1 13 |
5 15 |
4 5 22 |
3 6 8 9 12 |
1 4 10 13 |
12 19 |
3 7 12 20 |
1 | 7 20 |
2 17 |
11 | 8 | 2 6 7 19 |
4 5 6 10 16 |
2 17 |
2 4 |
3 11 |
2 6 14 |
12 | 1 | 21 |
|
NLE chromosomes contributing to each human chromosome
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| HSA |
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
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12
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13
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14
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15
|
16
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17
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18
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19
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20
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21
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22
|
| NLE | 5 9 12 24 |
14 17 19 20 22b |
4 8 11 21 |
7 9 18 20 |
2 6 7 18 |
1b 3 8 17 18 22 |
11 13 17 |
4 8 16 |
1b 8 |
3 9 18 |
4 15 21 |
8 10 11 23 |
5 9 |
1b 22b |
6 | 2 18 |
14 19 |
4 | 10 17 |
11 13 |
25 | 7 |
FISH examples of splitting clones (see also NLE chromosome-specific pages)
| Split in HSA (NLE probes) | Split in NLE (HSA probes) | |||||
|
clone
|
NLE
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HSA
|
clone
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HSA
|
NLE
|
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6b/9b2
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HSA1
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NLE 5/12
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9b1/9b4
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HSA1
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NLE 9/12
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5c1/16b1
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HSA2
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NLE 17/20
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5c2/16b1
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HSA2
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NLE 2/2
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18a1/18a2
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HSA6
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NLE 17/22
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5b/16a
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HSA7
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NLE 17/20
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1b1/1b3
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HSA8
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NLE 16/16
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7c1/7c2
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HSA9
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NLE 1b/8
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1c1/1c3
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HSA9
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NLE 1b/8 | ||||
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2d/7a1
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HSA10
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NLE 3/18
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2b2/17b4
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HSA16
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NLE 2/2 | ||||
| 14a1/14a2 |
HSA20
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NLE 11/13
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| Xa1/Xa2 |
HSA20
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NLE 11/13
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Examples of NLE probes yielding duplicated FISH signals
| Clone |
NLE
|
HSA
|
comment |
| CH271-71L9 | Signals, in NLE, in telomeric and other heterochromatic regions | ||
| CH271-139C8 | |||
| CH271-156E13 | Multiple signals | ||
| CH271-174G4 | Multiple signals | ||
| CH271-337F19 | Duplication | ||
| CH271-327M6 | Multiple signals | ||
| CH271-202C14 | Morpheus like | ||
| CH271-342G19 | Telomeric and interstitial heterochromatin | ||
| CH271-118P10 | Single s. in NLE; m.s., telomeric or pericentromeric, in HSA | ||
| CH271-330L11 | m. s. in NLE; faint signals in sone centromeres of HSA | ||
| CH271-146B14 | Multiple centromeric signals |