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PhD program in
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Genetics and Molecular and Structural Evolution
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Coordinated by Prof. Mariano Rocchi
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Cell mediated immunity |
Evolution of multigenic families in cell-mediated immunity
Genomic, functional and comparative analysis of T cell receptor genes in mammals
Published papers (selection) (click to download the pdf)
Di Tommaso S, Antonacci R, Ciccarese S, Massari S: Extensive analysis of D-J-C arrangements allows the identification of different mechanisms enhancing the diversity in sheep T cell receptor beta-chain repertoire. BMC Genomics 11:3 (2010)
Massari S, Bellahcene F, Vaccarelli G, Carelli G, Mineccia M, Lefranc MP, Antonacci R, Ciccarese S: The deduced structure of the T cell receptor gamma locus in Canis lupus familiaris. Mol Immunol 46:2728-36 (2009)
Vaccarelli G, Miccoli MC, Antonacci R, Pesole G, Ciccarese S: Genomic organization and recombinational unit duplication-driven evolution of ovine and bovine T cell receptor gamma loci. BMC Genomics 9:81 (2008)
Antonacci R, Di Tommaso S, Lanave C, Cribiu EP, Ciccarese S, Massari S: Organization, structure and evolution of 41kb of genomic DNA spanning the D-J-C region of the sheep TRB locus. Mol Immunol 45:493-509 (2008)
Miccoli MC, Vaccarelli G, Lanave C, Cribiu EP, Ciccarese S: Comparative analyses of sheep and human TRG joining regions: Evolution of J genes in Bovidae is driven by sequence conservation in their promoters for germline transcription. Gene 355:67-78 (2005)
Antonacci R, Lanave C, Del Faro L, Vaccarelli G, Ciccarese S, Massari S: Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes. Immunogenetics 57:254-266 (2005)
Vaccarelli G, Miccoli MC, Lanave C, Massari S, Cribiu EP, Ciccarese S: Genomic organization of the sheep TRG1@ locus and comparative analyses of Bovidae and human variable genes. Gene 357:103-114 (2005)
Miccoli MC, Antonacci R, Vaccarelli G, Lanave C, Massari S, Cribiu EP, Ciccarese S: Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus. J Mol Evol 57:52-62 (2003)
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