PhD program in
  Genetics and Molecular and Structural Evolution  
Coordinated by Prof. Mariano Rocchi

  Functional genomics

A.M. D'Erchia

The group is involved on studies focusing on:

- The transactivation activity of the p53 gene family aimed to the identification and functional characterization of new p53 family target genes in order to define the specific functions of the family in the cellular pathways;

- The high-throughput prediction and characterization of alternative transcripts in normal and pathologic human tissues through computational and experimental approaches.

Published papers (selection) (click to download the pdf)

Valletti A, Anselmo A, Mangiulli M, Boria I, Mignone F, Merla G, D'Angelo V, Tullo A, Sbisa' E, D'Erchia AM, Pesole G. Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation. Mol Cancer, 2010 9:230

Lefkimmiatis K., Caratozzolo M.F., Merlo P., D'Erchia A.M., Navarro B., Levrero M., Sbisa' E., Tullo A. P73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes. Cancer Res. 2009; 69:8563-71.

Mangiulli M., Valletti A., Caratozzolo M.F., Tullo A., Sbisa' E., Pesole G., D'Erchia A.M. Identification and functional characterization of two new transcriptional variants of the human p63 gene. NAR, 2009,  37:6092-6104 

Castrignano' T., D’Antonio M., Anselmo A., Carrabino D., D’Onorio De Meo P., D’Erchia A.M., Licciulli F. Mangiulli M., Mignone F., Pavesi G. Picardi E., Rizzi R., Bonizzoni P., Pesole G. ASPicDB: a database resource for alternative splicing analysisBioinformatics, 2008, 24:1300-4

Sbisa' E., Catalano D., Grillo G., Licciulli F., Turi A., Liuni S., Pesole G., De Grassi A., Caratozzolo M.F., D'Erchia A.M., Navarro B., Tullo A., Saccone C., and Gisel A. p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data. BMC Bioinformatics, 2007, 8(Suppl 1):S20

D’Erchia A.M., Tullo A., Lefkimmiatis K., Saccone C., Sbisa' E. The Fatty Acid Synthase gene is a conserved p53 family target from worm to human. Cell Cycle, 2006;5:750-758

Sbisa' E., Mastropasqua G., Lefkimmiatis K., Caratozzolo M., D’Erchia A.M., Tullo A. Connecting p63 to cell proliferation: the example of the Adenosine Deaminase  target gene. Cell Cycle, 2006;5:205-12.