PhD program in
  Genetics and Molecular and Structural Evolution  
Coordinated by Prof. Mariano Rocchi

  Drosophila evolution


Drosophila melanogaster as a model system to study mitochondrial dysfunction and disease and to the development of treatment strategies

Identification of conserved DNA sequence motifs involved in regulation of Drosophila bioenergetic gene expression

Published papers (selection) (click to download the pdf)

Pavesi G, Zambelli F, Caggese C, Pesole G: Exalign: a new method for comparative analysis of exon-intron gene structures. Nucleic Acids Res 36:e47 (2008)

Consortium... Caggese C, Porcelli D, Barsanti P... et al.: Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203-218 (2007)

Porcelli D, Barsanti P, Pesole G, Caggese C: The nuclear OXPHOS genes in insecta: a common evolutionary origin, a common cis-regulatory motif, a common destiny for gene duplicates. BMC Evol Biol 7:215 (2007)

Tripoli G, D'Elia D, Barsanti P, Caggese C: Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. Genome Biol 6:R11 (2005)

Sardiello M, Tripoli G, Romito A, Minervini C, Viggiano L, Caggese C, Pesole G: Energy biogenesis: one key for coordinating two genomes. Trends Genet 21:12-6 (2005)

De Grassi A, Caggese C, D'Elia D, Lanave C, Pesole G, Saccone C: Evolution of nuclearly encoded mitochondrial genes in Metazoa. Gene 354:181-188 (2005)